Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labourArticle Published on 2022-12-012022-11-15 Journal: Pharmaceutical Biology [Category] 치료제, [키워드] active against analysis antiviral activity antiviral drug antiviral drugs Asia Asian ChemSpider Direct distribution Google Scholar Hercule hydroxytyrosol identify in vivo material molecular natural plant PubChem RNA RNA virus RNA virus Science Treatment viral genome replication viral infections virus virus Web of Science with COVID-19 zoonotic [DOI] 10.1080/13880209.2022.2130944 PMC 바로가기
The impact of COVID-19 non-pharmaceutical interventions on HIV care continuum in China: An interrupted time series analysisResearch article Published on 2022-12-012022-10-05 Journal: The Lancet Regional Health - Western Pacific [Category] 변종, [키워드] 95% CI affected Analysis Antiretroviral therapy ART Care CD4 count CD4 counts CD4+ T cell China collected continuum COVID-19 decrease diagnose diagnoses Diagnosis disease early stage effort evaluate expected finding foundation funding HIV hospital implementation increase in Infectious disease Interrupted time series analysis interval Intervention maintain majority male median time natural non-pharmaceutical interventions (NPIs) NPI NPIs occurred outcome outcomes Poisson Prophylaxis public health emergency reached Region Regression model Science study period time interval time intervals Transmission were recorded [DOI] 10.1016/j.lanwpc.2022.100569 [Article Type] Research article
Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasionArticle Published on 2022-11-012022-11-15 Journal: Food and chemical toxicology : an international jo [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 antiviral effects binding caused complexes component components demonstrated exhibit FRET test Ganoderma lucidum triterpenoids hACE2 hACE2 receptor high affinity hydrogen bonds IC50 in vitro Infection inhibit inhibited inhibition assay Invasion Lucidenic acid A (PubChem CID: 14109375) molecular docking molecular dynamics Mutation natural natural products omicron Omicron variant omicron variant. pathway Potential Prevent PubChem receptor receptor proteins SARS-CoV-2 Spike protein stability target variant Virtual screening virus was selected were used [DOI] 10.1016/j.fct.2022.113438 PMC 바로가기
Natural humoral immunity per year after SARS-CoV-2 infection in hospitalized patientsArticle Published on 2022-11-012022-11-15 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 진단, [키워드] hospitalized patient Humoral immunity natural SARS-COV-2 infection [DOI] 10.1016/j.eimce.2022.04.007 PMC 바로가기
On the Recognition of Natural Substrate CTP and Endogenous Inhibitor ddhCTP of SARS-CoV-2 RNA-Dependent RNA Polymerase: A Molecular Dynamics StudyArticle Published on 2022-10-242022-11-15 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 치료제, [키워드] absence affecting Antiviral computational method COVID-19 outbreak Cryo-electron microscopy cytidine Dynamics endogenous enzyme help implication in silico information inhibitor inhibitory innate immune response investigated MD simulation mechanism molecular molecular mechanism multiple mutation natural novel coronavirus SARS-CoV-2 nucleotide pandemic Protein RdRP RdRp active site Recognition responsible RNA RNA sequence RNA-dependent RNA polymerase SARS-CoV-2 substrate viral replication virus [DOI] 10.1021/acs.jcim.2c01002 PMC 바로가기
Immune Response after the Fourth Dose of SARS-CoV-2 mRNA Vaccine Compared to Natural Infection in Three Doses’ Vaccinated Solid Organ Transplant RecipientsArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration analyzed booster booster dose booster doses Breakthrough infection cellular response CLIA Cohort COVID-19 dose Efficacy ELISA ELISpot assay fourth dose General population humoral IgA IgA level IgG immune immune response IMPROVE in both group Infection mRNA mRNA vaccine natural natural infection new SARS-CoV-2 no difference Organ transplant Patient positive recipient recipients repeated response SARS-CoV-2 SARS-COV-2 infection secretion serum IgG severe COVID-19 significant increase significantly increased Solid solid organ transplant Solid organ transplant recipients. Still T cell T-cell T-cell Response Transplant vaccination Vaccine vaccine-induced immune response variants of concern [DOI] 10.3390/v14102299 PMC 바로가기
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main ProteaseArticle Published on 2022-10-072022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome ADME ADMET antiviral drug betweenness Betweenness centrality binding site catalytic dyad Clinical treatment complex coronavirus COVID-19 database docking experiments drugs enzyme highest in silico In silico methods in vitro in vivo inhibitor inhibitory inhibitory effect Ligand molecular docking molecular dynamics MPro mutated variant natural natural products network network analysis offer pandemic Population potential mechanism predicted product protease Protein reported residue responsible risk SARS-CoV-2 SARS-CoV-2. severe COVID-19 Spread the SARS-CoV-2 trajectory Vaccine Vaccines viral replication WHO World Health Organization [DOI] 10.1007/s00894-022-05334-1 PMC 바로가기
Dynamic Evaluation of Natural Killer Cells Subpopulations in COVID-19 PatientsArticle Published on 2022-10-062022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Admission analyzed Blood blood sample CD16 CD56 Cell change circulation collected COVID-19 COVID-19 patients cytokine cytolytic disease dynamic early stage EDTA evaluate expression flow cytometry forms IFN lymphocyte natural Natural killer cells natural killer cells. NK cell no difference Non-survivors outcome outcomes patients PD-1 phenotype Prognostic value proportion SARS-CoV-2 SARS-COV-2 infection significantly study period subpopulation subtype Subtypes surface marker survival group survivor Total White blood cell [DOI] 10.3390/ijms231911875 PMC 바로가기
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregatesArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while [DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] activity antiviral activity antiviral drugs Antiviral effect antiviral property Boswellia Boswellia species bronchial asthma caused condition COVID-19 pandemic disease drugs Effect Efficacy exhibited Herbal herbal medicine natural Natural therapies pathogenic virus pharmacological plants provided reduction in reported Research SARS-CoV-2 SARS-CoV-2. therapeutic effect Topic Treatment Vaccine Viral diseases viral infection Viral resistance [DOI] 10.1007/s10787-022-01037-4 PMC 바로가기